Does a high-dose influenza vaccine cut back heart problems danger?

In a latest research revealed in JAMA Community Open, researchers assessed whether or not a high-dose influenza vaccine is related to a profit in decreasing cardiopulmonary (CP) occasions during times of influenza exercise.

Study: Temporal Association Among Influenza-Like Illness, Cardiovascular Events, and Vaccine Dose in Patients With High-Risk Cardiovascular Disease. Image Credit: BaLL LunLa/Shutterstock.comResearch: Temporal Affiliation Amongst Influenza-Like Sickness, Cardiovascular Occasions, and Vaccine Dose in Sufferers With Excessive-Danger Cardiovascular Illness. Picture Credit score: BaLL LunLa/


Influenza is related to a better danger of CP occasions. Seasonal influenza outbreaks primarily happen in winter when transmission is extra favorable. Furthermore, cardiovascular (CV) occasions exhibit related temporal patterns.

Research have reported associations between CV occasions and influenza. Moreover, observational research and trials recommend that the influenza vaccine may cut back opposed CV outcomes.

INVESTED, a randomized scientific trial, evaluated the effectiveness of the high-dose trivalent influenza vaccine over the standard-dose quadrivalent vaccine in folks with excessive CV danger throughout the 2016-19 influenza seasons.

It didn’t discover an elevated advantage of the excessive dose relative to the usual routine for the first endpoint. It’s unknown whether or not the efficacy of the therapy varies at instances of elevated influenza-like sickness (ILI) exercise.

Concerning the research

Within the current research, researchers examined whether or not high-dose influenza vaccine influenced the occasions related to ILI exercise. This was a pre-specified secondary evaluation of the desired trial performed throughout Canada and the USA (US) between September 2016 and July 2019.

Sufferers with excessive CV illness (CVD) danger beforehand hospitalized for myocardial infarction (MI) or coronary heart failure (HF) had been randomized to obtain a standard- or high-dose vaccine for influenza.

ILI was outlined by clinic visits for fever, sore throat, or cough with none identified trigger aside from influenza, as reported to the US Facilities for Illness Management and Prevention (CDC) outpatient ILI surveillance community.

The workforce included knowledge from 108 websites and territories. Race or ethnicity was self-reported by sufferers. The researchers used logistic regression fashions to check weekly ILI with the prevalence of the first and secondary outcomes.

The first end result was a composite of CP hospitalization or all-cause mortality. Secondary outcomes included pulmonary hospitalization, CV hospitalization, and demise. The temporal affiliation between publicity and growth was assessed utilizing weekly ILI exercise with as much as 9 weeks of lag from the end result.

Fashions had been adjusted for demographics, enrolment strata, state, and CV danger components. The weekly odds of the (prevalence of the) major end result by therapy group (standard- or high-dose) had been assessed utilizing logistic regression fashions.

Sensitivity analyses had been carried out to look at the associations of ILI exercise with outcomes during times of upper influenza or ILI exercise.


In whole, 3,094 US members aged, on common, 65, had been included. Practically 75% of topics had been males, 72.3% had been White, and 22.3% had been Black. About 12.1%, 21.7%, and 76% had a previous MI, HF hospitalization, and HF, respectively.

Total, 1,396 major end result occasions, 183 pulmonary hospitalizations, 1,141 CV hospitalizations, and 322 deaths occurred throughout 129,285 person-weeks of enrolment.

The best common ILI exercise was recorded throughout the 2017-18 season. Elevated ILI exercise previously week was related to elevated dangers of major end result occasions, CV hospitalization, and CP hospitalization. There was no affiliation of ILI exercise with pulmonary hospitalizations or all-cause mortality.

As well as, there was a decrease danger of those occasions throughout hotter months within the US (July to September). The high-dose influenza vaccine was not superior to the usual dose in its affiliation with the chance of major end result occasions, even when the evaluation was restricted to intervals of upper influenza or ILI exercise.


The findings demonstrated a temporal affiliation of ILI with CV and CP hospitalizations in excessive CVD-risk sufferers however not with all-cause mortality.

A better dose relative to the usual dose of the influenza vaccine didn’t affect this affiliation, even during times of upper ILI or influenza exercise. Moreover, there was an affiliation between hotter months and decreased CV danger, impartial of the native ILI exercise.

Though the good thing about vaccination relative to placebo was not decided, vaccination would possible be considerably helpful to placebo on this high-risk inhabitants.

Moreover, different respiratory viruses may additionally contribute to the affiliation since influenza will not be the one virus circulating in winter months.

Collectively, on this secondary evaluation of the INVESTED trial, influenza exercise was temporally related to a better danger of CP occasions. But, the upper vaccine dose didn’t cut back this danger.

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