Examine affords new perception into elevated threat of blood clots in girls

New analysis from Queen Mary College of London, printed in iScience, exhibits an elevated threat of blood clots in girls who’ve any mixture of a specific gene mutation, estrogen use, or widespread medical situations – particularly: weight problems, hypertension, excessive ldl cholesterol, and kidney illness.

Ladies with the Issue V Leiden (FVL) gene mutation who had been prescribed estrogen had greater than double the chance of blood clotting in comparison with girls who didn’t have this mutation. And virtually 20% of the ladies who carry FVL, had been prescribed estrogen and had two medical situations suffered a blood clot. The presence of the FVL gene made a considerable distinction to threat, with solely round 5% of girls taking estrogen and having two situations struggling a clotting occasion.

The examine additionally discovered {that a} girl with weight problems, hypertension, excessive ldl cholesterol, and kidney illness – which isn’t unusual in a scientific setting – had an 8 instances higher likelihood of blood clotting in comparison with a lady with none of those situations. This amounted to roughly one in each six girls with the 4 situations within the examine struggling a blood clot. Three medical situations meant a 5 instances higher likelihood of blood clotting, and two medical situations meant a two instances higher likelihood.

One in three girls who had the FVL gene mutation and three of the medical situations examined additionally suffered a blood clotting occasion.

The researchers examined the well being information of 20,048 British-Bangladeshi and British-Pakistani girls from the Genes & Well being venture, a big community-based genetics examine. Whereas estrogen use, FVL, and customary medical situations are all recognized threat components of blood clots, research haven’t regarded on the mixed threat of those components collectively on blood clot prevalence.

Ladies are generally prescribed estrogen, each by means of oral contraception containing the hormone and as a part of hormone substitute remedy to interchange the estrogen that their physique stops making throughout menopause.

Many ladies will take estrogen sooner or later of their lifetime. General, that is very protected and there are much more positives to taking it than negatives when it is prescribed. However these girls might not be conscious of the mixed threat of their genetics and total well being and the way it impacts their threat of creating a blood clot, which could possibly be life-threatening for some people.

It is vital that girls have all the data they should make an knowledgeable selection. Whereas our outcomes are vital for ladies all over the place, they’re particularly related for South Asian girls with a number of current well being situations.»

Dr Emma Magavern, lead creator, Queen Mary College of London

Professor Sir Mark Caulfield, from Queen Mary College of London, mentioned: «Our examine provides a extra full image of blood clotting in Bangladeshi and Pakistani communities who’ve beforehand been underrepresented in analysis.

«Genetic testing of the FVL gene mutation may give a clearer sense of somebody’s personalised threat of this probably deadly complication in the event that they had been prescribed estrogen.»

This work was funded by the Nationwide Institute for Well being and Care Analysis Barts Biomedical Analysis Centre and Barts Charity.


Journal reference:

Magavern, E. F., et al. (2023) Issue V Leiden, oestrogen and multimorbidity affiliation with venous thromboembolism in a British-South Asian Cohort. iScience. doi.org/10.1016/j.isci.2023.107795.

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