Lengthy COVID danger discovered to be considerably decrease following Omicron an infection

The danger of growing lengthy COVID is considerably decrease following an an infection with the Omicron variant than after an an infection with earlier coronavirus variants. This was the discovering of a research by College Medication Halle, which was revealed within the «Worldwide Journal of Infectious Illnesses». The evaluation checked out data gathered from 11,000 individuals about their an infection historical past, vaccination standing, and post-infection signs. The information present sturdy proof that the chance for long-term results after a re-infection with the coronavirus is decrease if the affected person didn’t develop lengthy COVID after the preliminary an infection.

Lengthy-term signs can develop after a coronavirus an infection. That is generally known as «lengthy COVID» or «Submit COVID-19 situation». The underlying danger elements are at the moment beneath intensive investigation. «We needed to know the connection between lengthy COVID and totally different coronavirus variants, vaccinations, and previous infections,» explains Sophie Diexer, first writer of the brand new research and researcher on the Institute of Medical Epidemiology, Biometry and Informatics at College Medication Halle. «Our research reveals that the share of people that develop lengthy COVID signs after an an infection was lowest on the time when Omicron was prevalent.» The danger was discovered to be round three to 4 instances decrease after an Omicron an infection than after an an infection with the wild-type variant. Round half of all wild-type contaminated people reported persisting signs. It must be famous, nonetheless, that almost all of all infections occurred whereas Omicron was dominant. «In purely numerical phrases, which means that most individuals developed lengthy COVID following an Omicron an infection,» says Diexer.

The research additionally supplies sturdy proof of a protecting impact as soon as the affected person has recovered from a coronavirus an infection. «Individuals who didn’t develop persistent signs after their preliminary an infection had a considerably decrease danger of growing lengthy COVID following re-infection than individuals who have been contaminated with the coronavirus for the primary time. We have been shocked by the size of this impact,» explains the researcher. Nevertheless, the scientists have been unable to reveal that, within the occasion of a vaccine breakthrough, the vaccine had any protecting impact towards lengthy COVID. Because of the timing of the research, nonetheless, it was not doable to research the vaccine that particularly focused the Omicron variant.

The research is predicated on the Germany-wide DigiHero venture, which greater than 48,000 individuals participated in till June 2022. «Research have already regarded on the relationship between the chance of lengthy COVID and the totally different variants, however none has taken into consideration an infection historical past,» explains Professor Rafael Mikolajczyk, director of the Institute of Medical Epidemiology, Biometry and Informatics at College Medication Halle. «Of the respondents, roughly 11,000 reported no less than one coronavirus an infection that had occurred within the twelve weeks previous to when the info was collected for our research. Classification was based mostly on the predominant variant on the time of the reported an infection.» Individuals have been questioned about 24 typical lengthy COVID signs, with 2,822 people reporting that they’d skilled such signs. Of those, 406 (14 per cent) reported experiencing extreme fatigue, 237 (8 % ) extreme complications, and 202 (7 per cent) extreme shortness of breath. The depth of the signs was not associated to the coronavirus variant.

Comply with-up surveys are at the moment being carried out to discover the persistence of lengthy COVID signs. «Along with doable long-term signs following a coronavirus an infection, DigiHero is addressing a variety of well being points and different impacts of the COVID-19 pandemic,» provides Mikolajczyk. On the idea of DigiHero, College Medication Halle has additionally launched the Lengthy COVID Registry in cooperation with Otto von Guericke College Magdeburg and the Rechts der Isar Hospital of the TUM College of Medication. The registry information, for instance, lengthy COVID signs in addition to their development, severity and alleviation by way of particular therapies.


DigiHero is a Germany-wide, population-based digital well being analysis research (www.medizin.uni-halle.de/digihero). Up to now, over 90,000 individuals from 14 German states have registered. Individuals are invited to finish on-line surveys that discover points surrounding the event of continual illness, wholesome growing old, well being behaviors, and the coronavirus. 5 clinics and 4 institutes from College Medication Halle are collaborating. Different venture companions embody Jena College Hospital, the Leibniz Institute for Prevention Analysis and Epidemiology – BIPS, and the College of Bremen.


Journal reference:

Diexer, S., et al. (2023) Affiliation between Virus Variants, Vaccination, Earlier Infections, and Submit COVID-19 Danger. Worldwide Journal of Infectious Illnesses. doi.org/10.1016/j.ijid.2023.08.019.

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